Trisomy-X with estrous cycle anomalies in two female dogs |
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Authors: | O'Connor C L Schweizer C Gradil C Schlafer D Lopate C Prociuk U Meyers-Wallen V N Casal M L |
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Affiliation: | a Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA b Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA c Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA d Reproductive Revolutions, Inc., Aurora, Oregon, USA e Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA |
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Abstract: | Two female dogs were presented with a history of abnormal estrous cycles and infertility, despite multiple breedings. Medical therapy to correct the cycle anomalies did not result in pregnancy. Cytogenetic analysis of blood lymphocyte cultures in each dog revealed three copies of the X chromosome in each cell, constituting a 79,XXX karyotype (trisomy-X). Both dogs were eventually ovariohysterectomised and histological evaluation revealed hypoplastic ovaries and an absence of normal follicular structures. However, partial or immature follicles were noted, which may have been sufficient to cause both females to initiate cycling. The history and clinical characteristics found in these dogs were compared to those described in three other dogs reported with trisomy-X, as well as those reported in other species. These findings highlighted the importance of cytogenetic studies in fertility evaluation and achieving a definitive diagnosis for infertility in the bitch. |
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Keywords: | Dog Infertility Karyotype Aneuploidy XXX Abnormal estrous cycle |
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