|
|||||
|
|
| 源于一株青霉菌的4,5-环氧环己烯类次生代谢产物研究 | |
| 引用本文： | 文浩,李彦,刘杏忠,高昊,姚新生.源于一株青霉菌的4,5-环氧环己烯类次生代谢产物研究[J].菌物学报,2012,31(2):267-274. |
| 作者姓名： | 文浩 李彦 刘杏忠 高昊 姚新生 |
| 作者单位： | 1. 暨南大学药学院 中药及天然药物研究所 广东广州510632 2. 军事医学科学院 毒物药物研究所 北京100850 3. 中国科学院微生物研究所 真菌学国家重点实验室 北京100101 |
| 基金项目： | 国家自然科学基金（No. 30925039）；北京自然科学基金（No. 5111003） |
| 摘 要： | 从一株青霉菌Penicillium sp.（XZ075）的发酵粗提物中分离了4个4,5-环氧环己烯类新结构次生代谢产物penoxides A－D（1－4）和同类型的已知化合物eupenoxide（5），并采用质谱和核磁共振技术确定了新化合物的结构。化合物1的绝对构型是通过与已知化合物5比对核磁数据确定的，而2－4的绝对构型是通过与化合物1比对CD谱图确定的。活性测试结果表明化合物1，2及4对宫颈癌细胞（HeLa）具有中等的细胞毒活性。 |
| 关 键 词： | Penicillium sp. 4 5-环氧环己烯类化合物 结构鉴定 细胞毒活性 |
4,5-epoxycyclohexenoid derivatives from the fungus Penicillium sp. |
|
| Authors: | WEN Hao LI Yan LIU Xing-Zhong GAO Hao and YAO Xin-Sheng |
| Institution: | Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China;Institute of Pharmacology & Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China;Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China |
| Abstract: | Four new 4,5-epoxycyclohexenoids,penoxides A-D(1-4),and a known analogue,eupenoxide(5),have been isolated from the crude extract of Penicillium sp.The structures of 1-4 were elucidated primarily by mass spectrum(MS) and nuclear magnetic resonance(NMR) techniques.The absolute configuration of 1 was deduced by comparison of its NMR data with those of 5,whereas those of 2-4 were deduced by comparison of their CD spectra with that of 1.Compounds 1,2 and 4 showed modest cytotoxicity against HeLa cells. |
| Keywords: | Penicillium sp 4 5-epoxycyclohexenoids structure elucidation cytotoxicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《菌物学报》浏览原始摘要信息 | |
| 点击此处可从《菌物学报》下载免费的PDF全文 | |