Parallel-stranded hairpins containing 8-aminopurines. Novel efficient probes for triple-helix formation. |
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| Authors: | A Avi?ó J C Morales M Frieden B G de la Torre R G García E Cubero F J Luque M Orozco F Azorín R Eritja |
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| Affiliation: | Cygene Spain S.L., Parc Científic de Barcelona, Baldiri i Reixac, 10-12, E-08028, Barcelona, Spain. |
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| Abstract: | We describe novel oligomers with a greater propensity to form triplexes than oligomers containing only natural bases. They consist of a polypyrimidine sequence linked head-to-head with a polypurine sequence carrying one or several 8-aminoadenine or 8-aminoguanines. The presence of 8-aminopurines also stabilised the parallel-stranded duplex structure. |
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