Dynamic simulations on the mitochondrial fatty acid Beta-oxidation network |
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Authors: | Robert Modre-Osprian Ingrid Osprian Bernhard Tilg Günter Schreier Klaus M Weinberger Armin Graber |
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Affiliation: | (1) eHealth systems, Biomedical Engineering, Austrian Research Centers GmbH – ARC, Eduard Wallnoefer Zentrum 1, 6060 Hall in Tirol, Austria;(2) BIOCRATES life sciences AG, Innrain 66/2, 6020 Innsbruck, Austria;(3) Institute for Biomedical Engineering, UMIT, Eduard Wallnoefer Zentrum 1, 6060 Hall in Tirol, Austria;(4) Institute for Bioinformatics, UMIT, Eduard Wallnoefer Zentrum 1, 6060 Hall in Tirol, Austria |
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Abstract: | Background The oxidation of fatty acids in mitochondria plays an important role in energy metabolism and genetic disorders of this pathway may cause metabolic diseases. Enzyme deficiencies can block the metabolism at defined reactions in the mitochondrion and lead to accumulation of specific substrates causing severe clinical manifestations. Ten of the disorders directly affecting mitochondrial fatty acid oxidation have been well-defined, implicating episodic hypoketotic hypoglycemia provoked by catabolic stress, multiple organ failure, muscle weakness, or hypertrophic cardiomyopathy. Additionally, syndromes of severe maternal illness (HELLP syndrome and AFLP) have been associated with pregnancies carrying a fetus affected by fatty acid oxidation deficiencies. However, little is known about fatty acids kinetics, especially during fasting or exercise when the demand for fatty acid oxidation is increased (catabolic stress). |
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