Vitamin Pharmacogenomics: New Insight into Individual Differences in Diseases and Drug Responses |
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| Authors: | Hai-Yan He Mou-Ze Liu Yue-Li Zhang Wei Zhang |
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| Affiliation: | 1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China;2. Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China;3. International Medical Department, Xiangya Hospital, Central South University, Changsha 410008, China;4. National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China |
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| Abstract: | Vitamins are vital to sustain normal physiological function, metabolism, and growth for all living organisms. Being an integral component of coenzyme, vitamins can affect the catalytic activities of many enzymes and the expression of drug transporters. Genetic variations in metabolism and/or transporter genes of drugs can influence the exposure of the human body to drugs and/or their active metabolites, thus contributing to the variations in drug responses and toxicities. Nonetheless, pharmacogenomics studies on nutrients have been rarely summarized. In this article, we reviewed recent progress on vitamin pharmacogenomics, for a better understanding on the influence of vitamin-related gene polymorphisms on inter-individual differences in diseases and drug efficacy and safety. |
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| Keywords: | Vitamin Pharmacogenomics Single nucleotide polymorphism Genetic variation Individual difference |
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