Anti-fatigue activity of a Lachnum polysaccharide and its carboxymethylated derivative in mice |
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Authors: | Maheen Mahwish Surhio Yufen Wang Shi Fang Jinglei Li Ming Ye |
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Affiliation: | Microbial Resources and Application Laboratory, College of Food Science and Engineering, Hefei University of Technology, Hefei 230009, China |
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Abstract: | The present study was designed to evaluate the anti-fatigue activity of an exopolysaccharide LEP-1b and its carboxymethylated derivative CLEP-1b from a Lachnum sp. Carboxymethylation was confirmed through FT-IR and 13C NMR spectroscopies, which showed that the (–CH2COOH) group was attached to an oxygen (O) atom of the hydroxyl group on (C-3) of LEP-1b. Each treatment group LEP-1b and CLEP-1b at doses (50, 100, 200 mg/kg, respectively) ameliorated physical fatigue and extended exhaustive swimming time in mice. Results of the fatigue related biochemical markers showed that LEP-1b and CLEP-1b at doses (50, 100, 200 mg/kg, respectively) increased the content of hepatic glycogen and decreased the level of serum urea nitrogen and lactic acid. Additionally, LEP-1b and CLEP-1b enhanced the antioxidant enzymes’ activities and reduced the lipid peroxidation. Moreover, results revealed that CLEP-1b had higher anti-fatigue activity than LEP-1b at same doses but without statistical significance, especially CLEP-1b (200 mg/kg) had strong anti-fatigue effects. Therefore, LEP-1b and CLEP-1b can potentially be exploited as a kind of healthcare compound to combat fatigue and to boost physical strength. |
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Keywords: | Carboxymethylation Anti-fatigue activity |
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