Photodynamic effect of meso-(aryl)porphyrins and meso-(1-methyl-4-pyridinium)porphyrins on HaCaT keratinocytes |
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Authors: | Amanda M Slomp Sandra MW Barreira Luise ZB Carrenho Camila C Vandresen Ingrid F Zattoni Stephanie MS Ló Juliana CC Dallagnol Diogo RB Ducatti Alexandre Orsato M Eugênia R Duarte Miguel D Noseda Michel F Otuki Alan G Gonçalves |
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Institution: | 1. Departamento de Farmácia, Universidade Federal do Paraná, Av. Lothario Meissner, 3400, Jardim Botânico, Curitiba, Paraná, Brazil;2. Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, PO Box 19046, Curitiba, Paraná, Brazil;3. Departamento de Farmacologia, Universidade Federal do Paraná, PO Box 19031, Curitiba, Paraná, Brazil |
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Abstract: | Sixteen porphyrins, including neutral, anionic and cationic meso-(aryl)porphyrins and meso-(1-methyl-4-pyridinium)porphyrins were herein evaluated in terms of their photosensitizing properties against HaCaT keratinocytes. After an initial screening, the cationic porphyrins were studied in more details, by both determining their log POW and performing PDT assays in lower porphyrin concentrations. Porphyrins presenting two or more adjacent positively charged groups, directly linked to the macrocycle meso positions, appeared to be the most effective photosensitizers. The present study also included the dicationic 5,10-diphenyl-15,20-di(1-methylpyridinium-4-yl)porphyrin (14b), which has previously shown promising results on a psoriasis-like in vivo model. Overall results indicated that the beneficial effect related to porphyrins on psoriasis can be related to the decreasing of keratinocyte viability. Furthermore, some of the cationic porphyrins studied appeared as candidates to be utilized as photosensitizers for psoriasis treatment. |
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Keywords: | Porphyrins Photodynamic therapy (PDT) HaCaT keratinocytes Photosensitizer Psoriasis |
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