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Imidazopyridyl compounds as aldosterone synthase inhibitors |
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| Authors: | Brent R. Whitehead Michael M.-C. Lo Amjad Ali Min K. Park Scott B. Hoyt Yusheng Xiong Jiaqiang Cai Emma Carswell Andrew Cooke John MacLean Paul Ratcliffe John Robinson D. Jonathan Bennett Joseph A. Clemas Tom Wisniewski Mary Struthers Doris Cully Douglas J. MacNeil |
| Affiliation: | 1. MRL, Rahway, NJ 07065, USA;2. MRL, Newhouse, Lanarkshire ML1 5SH, United Kingdom |
| Abstract: | The inhibition of aldosterone synthase (CYP11B2) may be an effective treatment of hypertension and heart failure, among other ailments. Previously reported benzimidazole CYP11B2 inhibitors led the way for bioisosteric imidazopyridines that are both potent and selective over CYP11B1. |
| Keywords: | Aldosterone CYP11B2 Hypertension Imidazopyridine Heart failure |
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