Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines |
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Authors: | Michelle van Rensburg Euphemia Leung Natalie A. Haverkate Chatchakorn Eurtivong Lisa I. Pilkington Jóhannes Reynisson David Barker |
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Affiliation: | 1. School of Chemical Sciences, University of Auckland, New Zealand;2. Auckland Cancer Society Research Centre and Department of Molecular Medicine and Pathology, University of Auckland, New Zealand |
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Abstract: | 3-Amino-2-arylcarboxamide-thieno[2,3-b]pyridines are a known class of antiproliferative compounds with activity against the phospholipase C enzyme. To further investigate the structure activity relationships of these derivatives a series of analogues were prepared modifying key functional groups. It was determined that modification of the 3-amino and 2-aryl carboxamide functionalities resulted in complete elimination of activity, whilst modification at C-5 allowed compounds of greater activity to be prepared. |
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Keywords: | Cancer Phospholipase C Tyrosyl-DNA phosphodiesterase I Antiproliferative |
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