| Institution: | 1. Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA;2. Department of Pathology & Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, USA;3. Dana‐Farber Cancer Institute, Boston, MA, USA;4. Harvard Medical School, Boston, MA, USA;5. Department of Microbiology, School of Medicine, University of Minnesota, Minneapolis, MN, USA;6. Centers for Disease Control and Prevention, Atlanta, GA, USA;7. Department of Radiology, School of Medicine, Emory University, Atlanta, GA, USA |
| Abstract: | A Chinese rhesus macaque infected with the pathogenic CCR5‐tropic clade C simian‐human immunodeficiency virus, SHIV‐1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV‐infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV. |
