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Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells
Authors:Veerle Fleskens  Carlos M. Minutti  Xingmei Wu  Ping Wei  Cornelieke E.G.M. Pals  James McCrae  Saskia Hemmers  Vincent Groenewold  Harm-Jan Vos  Alexander Rudensky  Fan Pan  Huabin Li  Dietmar M. Zaiss  Paul J. Coffer
Affiliation:1. Center for Molecular Medicine, Division of Pediatrics, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands;2. Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK;3. ENT Department, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China;4. Regenerative Medicine Center, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands;5. Immunology Program, Howard Hughes Medical Institute, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA;6. Hubrecht Institute, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands;7. Proteins at Work, UMC Utrecht, Utrecht, the Netherlands;8. Immunology and Hematopoiesis Division, Department of Oncology, Bloomberg-Kimmel Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA;9. Department of Otolaryngology, The Children’s Hospital of Chongqing Medical University, 136 Zhongshaner Road, Chongqing 400014, China
Abstract:
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  • Keywords:Foxp3  phosphorylation  regulatory T cell  NLK  TCR  ubiquitination  immune tolerance
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