Spontaneous gallbladder pathology in baboons |
| |
| Authors: | J.L. Slingluff J.T. Williams L. Blau A. Blau E.J Dick Jr G.B. Hubbard |
| |
| Affiliation: | 1. College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, USA;2. Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, USA;3. School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA |
| |
| Abstract: | Background Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. Methods A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. Results Ninety‐seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). Conclusion Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans. |
| |
| Keywords: | bile cholecystitis cholelithiasis gallstones non‐human primate Papio |
|
|
