Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA) |
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Authors: | Sean G. Forrester Joshua Foster Sebastien Robert Lidya Salim Jean-Paul Desaulniers |
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Affiliation: | Faculty of Science, University of Ontario Institute of Technology, Oshawa, ON L1H 7K4, Canada |
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Abstract: | Investigations into the pharmacology of different types of cys-loop GABA receptor have relied for years on the chemical modification of GABA-like compounds. The GABA metabolite GABOB is an attractive molecule to modify due to its convenient chemical structure. In the process of developing new GABA-mimic compounds from GABOB as a starting compound three small molecule GABA derivatives were synthesized using a variety of chemical transformations. Amongst these, a new and reliable method to synthesize TACA (trans-4-aminocrotonic acid) is reported. |
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Keywords: | GABA TACA GABOB |
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