Hybrid DNA i-motif: Aminoethylprolyl-PNA (pC5) enhance the stability of DNA (dC5) i-motif structure |
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| Authors: | Chandrasekhar Reddy Gade Nagendra K Sharma |
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| Institution: | School of Chemical Sciences, National Institute of Science Education and Research (NISER), HBNI-Mumbai, Bhubaneswar, Jatni 752050, Odisha, India |
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| Abstract: | This report describes the synthesis of C-rich sequence, cytosine pentamer, of aep-PNA and its biophysical studies for the formation of hybrid DNA:aep-PNAi-motif structure with DNA cytosine pentamer (dC5) under acidic pH conditions. Herein, the CD/UV/NMR/ESI-Mass studies strongly support the formation of stable hybrid DNA i-motif structure with aep-PNA even near acidic conditions. Hence aep-PNA C-rich sequence cytosine could be considered as potential DNA i-motif stabilizing agents in vivo conditions. |
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| Keywords: | Hybrid i-motif DNA Ion-ion interaction Enhanced stability |
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