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Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors |
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| Authors: | Aaron Smith Zhi-Jie Ni Daniel Poon Zilin Huang Zheng Chen Qiong Zhang Laura Tandeske Hanne Merritt Kevin Shoemaker John Chan Susan Kaufman Kay Huh Jeremy Murray Brent A Appleton Sandra W Cowan-Jacob Clemens Scheufler Takanori Kanazawa Johanna M Jansen Cynthia M Shafer |
| Institution: | 1. Global Discovery Chemistry/Oncology & Exploratory Chemistry, Novartis Institutes for Biomedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States;2. Novartis Institutes of Biomedical Research, Novartis Campus, CH-4056 Basel, Switzerland |
| Abstract: | A series of imidazo1,2-a]pyridin-6-yl-benzamide analogs was designed as inhibitors of B-RAFV600E. Medicinal chemistry techniques were employed to explore the SAR for this series and improve selectivity versus P38 and VEGFR2. |
| Keywords: | MAPK RAF Kinase |
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