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Design,synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists |
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| Authors: | Xuqing Zhang Chaozhong Cai Michael Winters Michele Wells Mark Wall James Lanter Zhihua Sui Jingyuan Ma Aaron Novack Imad Nashashibi Yuanping Wang Wen Yan Arthur Suckow Hong Hua Austin Bell Peter Haug Wilma Clapper Celia Jenkinson William V Murray |
| Institution: | 1. Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, PA 19477, United States;2. CymaBay Therapeutics, Inc., 7999 Gateway Blvd, Newark, CA 94560, United States |
| Abstract: | A novel series of 5-membered heterocycle-containing phenylpropanoic acid derivatives was discovered as potent GPR120 agonists with low clearance, high oral bioavailability and in vivo antidiabetic activity in rodents. |
| Keywords: | GPR120 Type 2 diabetes Phenylpropanoic acid |
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