Antimicrobial activity of bitespiramycin,a new genetically engineered macrolide |
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| Authors: | Weiqing He Chunping Yang Xiaofeng Zhao Yiguang Wang |
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| Affiliation: | 1. Key Laboratory of Biotechnology of Antibiotics, The National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, No. 1 Tian Tan Xi Li, Beijing 100050, PR China;2. Shen Yang Tonglian Group Co., Ltd., Dadong District, Shen Yang 110042, PR China |
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| Abstract: | The antimicrobial activity of bitespiramycin (BT) against Chlamydia trachomatis (Ct), Chlamydia pneumoniae (Cp), Ureaplasma urealyticum (Uu), and Mycoplasma pneumoniae (Mp), was compared with those of azithromycin (AZM) and acetylspiramycin (AT-SP) in vitro. Furthermore, the anti-Mp activities of BT and AZM were evaluated in a hamster model. The activities of BT in vitro were similar to those of AZM but were more effective than those of AT-SP. BT effectively inhibited Mp infection at a dose of 200 mg/kg in a hamster model. |
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| Keywords: | Antimicrobial activity Bitespiramycin Infection |
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