Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia |
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Authors: | Zhaodi Xie Xiaoting Luo Zhuan Zou Xiao Zhang Feifei Huang Ruishan Li Shijie Liao Yun Liu |
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Institution: | 1. First Affiliated Hospital, Guangxi Medical University, Nanning, PR China;2. Department of Orthopedics, First Affiliated Hospital, Guangxi Medical University, Nanning, PR China |
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Abstract: | A series of hydroxychalcone derivatives have been designed, synthesized and evaluated for human xanthine oxidase (XO) inhibitory activity. Most of the tested compounds acted moderate XO inhibition with IC50 values in the micromolar rang. Molecular docking and kinetic studies have been performed to explain the binding modes of XO with the selected compounds. In addition, in vitro antioxidant screening results indicated that some of the hydroxychalcones possessed good anti-free radical activities. Furthermore, the preferred compounds 16 and 18 were able to significantly inhibit hepatic xanthine oxidase activity and reduced serum uric acid level of hyperuricemic mice in vivo. In summary, compounds 16 and 18 with balanced activities of antioxidant, XO inhibition and serum uric acid reduction, which are promising candidates for the treatment of hyperuricemia and gout. |
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Keywords: | DQFBYFPFKXHELB-VAWYXSNFSA-N AETKQQBRKSELEL-ZHACJKMWSA-N PACTXFWSVIDIEX-MDZDMXLPSA-N UAHGNXFYLAJDIN-IZZDOVSWSA-N UDOOPSJCRMKSGL-ZHACJKMWSA-N FGLRWHNZUBAWJK-MDZDMXLPSA-N PWWCDTYUYPOAIU-DHZHZOJOSA-N KSHCTKZLHCSARH-MDZDMXLPSA-N BLEVPIDFNNFTHJ-CMDGGOBGSA-N JUMSUVHHUVPSOY-RMKNXTFCSA-N FZQLEXXZAVVCCA-XCVCLJGOSA-N CSCFYIQZNHRESD-RUDMXATFSA-N VXDWUWKYEMWDDM-RMKNXTFCSA-N LKNPFZQVNZFLIC-VQHVLOKHSA-N FGPJTMCJNPRZGF-JXMROGBWSA-N MACMAADVRVVHBD-VMPITWQZSA-N WKMQGQZPDSFACZ-QPJJXVBHSA-N DXDRHHKMWQZJHT-FPYGCLRLSA-N Xanthine oxidase Hydroxychalcone derivatives Antioxidant Hyperuricemia |
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