|
|||||
|
|
Discovery of highly potent,selective, covalent inhibitors of JAK3 |
|
| Authors: | James Kempson Damaso Ovalle Junqing Guo Stephen T. Wrobleski Shuqun Lin Steven H. Spergel James J.-W. Duan Bin Jiang Zhonghui Lu Jagabandhu Das Bingwei V. Yang John Hynes Hong Wu John Tokarski John S. Sack Javed Khan Gary Schieven Yuval Blatt William J. Pitts |
| Affiliation: | Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA |
| Abstract: | A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design was based on crystal structure information and a comparative study of several electrophilic warheads. |
| Keywords: | JAK3 Covalent Irreversible inhibitor |
| 本文献已被 ScienceDirect 等数据库收录！ | |