Hematological,biochemical, respiratory,cardiovascular and electroneurophysiological parameters in African green monkeys (Cercopithecus aethiops sabaeus). Its use in non‐clinical toxicological studies |
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| Authors: | Angel Casacó Irene Beausoleil Bárbara Gonzalez Patricia Luaces Avelina León María E Arteaga Pavel Prado Valia Rodríguez Aylén Pérez Grisel Guevara Ana M Bada Nuris Ledón Dasha Fuentes Consuelo González Osvaldo Hernandez Romy Orphee Diuris Blanco Miriam García‐Osuma Alcides Ballester‐Labrada |
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| Institution: | 1. Centro de Inmunología Molecular (CIM), Siboney, Playa, Habana, Ciudad de La Habana, Cuba;2. Centro Nacional para la Producción de Animales de Laboratorio (CENPALAB), Finca Tirabeque, Carretera El Cacahual, Bejucal, La Habana, Cuba;3. Centro de Neurociencias de Cuba, Avenida, Cubanacán, Playa, Ciudad de La Habana, Cuba;4. Centro de Investigaciones Médico Quirúrgicas (CIMEQ), Siboney, Playa, Ciudad de La Habana, Cuba;5. Centro de Investigaciones Clínica, Kohly, Playa, La Habana, Cuba |
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| Abstract: | Background The purpose of this study is to better characterize the hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in young adult Cercopithecus aethiops sabaeus of both sexes. The rhesus and cynomolgus monkeys are widely used as experimental primate models. However, only few articles have been published testing toxicological effects of pharmaceuticals on African green monkey. Methods The present study was carried out with the recompilation of all parameters recorded before the first drug administration in five sub‐chronic or chronic toxicological studies performed on 66 Cercopithecus aethiops sabaeus, born in Cuba. Results This study provides hematological, biochemical, respiratory, cardiovascular and electroneurophysiological data for both choosing animals to be included into experiments and monitoring these parameters during the study. Conclusions We conclude that this study provides valuable integrated data for determining the health status, including electroneurophysiological parameters, data not previously reported for this species, of the African green monkey. |
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| Keywords: | Grivet monkeys Old World monkeys safety studies |
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