| 丙酮丁醇梭菌的基因编辑工具及代谢工程改造 |
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| 引用本文： | 薛闯,杜广庆. 丙酮丁醇梭菌的基因编辑工具及代谢工程改造[J]. 微生物学杂志, 2019, 0(4): 1-9 |
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| 作者姓名： | 薛闯 杜广庆 |
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| 作者单位： | 大连理工大学生物工程学院 |
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| 基金项目： | 国家自然科学基金项目(21576045，21376044)； 中央高校基本科研业务费专项资金资助项目（DUT16YQ103)； 辽宁省“兴辽英才计划”项目(XLYC1807269) |
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| 摘 要： | 丙酮丁醇梭菌作为极具潜力的新型生物燃料丁醇的生产菌,受到各国研究学者的广泛关注。通过丙酮丁醇梭菌(ABE)发酵生产丁醇,由于生产成本高,限制了其工业化应用。随着基因组学和分子生物学的快速发展,适用于丙酮丁醇的基因编辑工具不断发展并应用于提高菌株的发酵性能。本文对丙酮丁醇梭菌基因编辑工具和代谢工程改造取得的进展进行综述。
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| 关 键 词： | 丙酮丁醇梭菌；基因编辑；ABE发酵；丁醇 |
Genome editing tools and metabolic engineering in Clostridium acetobutylicum |
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| XUE Chuang and DU Guang-qing. Genome editing tools and metabolic engineering in Clostridium acetobutylicum[J]. Journal of Microbiology, 2019, 0(4): 1-9 |
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| Authors: | XUE Chuang and DU Guang-qing |
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| Affiliation: | School of Bioengineering, Dalian University of Technology, Dalian 116023 and School of Bioengineering, Dalian University of Technology, Dalian 116023 |
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| Abstract: | Clostridium acetobutylicum has gained worldwide attentions as a producer of bio butanol. However, the bio-butanol production via acetone butanol ethanol (ABE) fermentation is not economically competitive, which has hampered its industrial application. With the development of genomics and molecular biology, the genome editing tools available for Clostridium acetobutylicum were developed and applicated for strain improvement. This review focuses on the current status of genome editing tools and metabolic engineering in Clostridium acetobutylicum. |
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| Keywords: | Clostridium acetobutylicum genome editing ABE fermentation butanol |
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