| 梅毒螺旋体疫苗的研究进展 |
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| 引用本文： | 郑康,刘安元,吴移谋. 梅毒螺旋体疫苗的研究进展[J]. 微生物与感染, 2019, 14(3): 180-184. DOI: 10.3969/j.issn.1673-6184.2019.03.007 |
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| 作者姓名： | 郑康 刘安元 吴移谋 |
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| 作者单位： | 南华大学衡阳医学院病原生物学研究所,衡阳,421001;南华大学衡阳医学院病原生物学研究所,衡阳421001;南华大学附属第二医院,衡阳 421001 |
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| 基金项目： | 国家自然科学基金(81471576、81702046) |
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| 摘 要： | 梅毒是由密螺旋体苍白亚种( Treponema pallidum subsp. pallidum , Tp)感染引起的慢性系统性性传播疾病,流行于中低等收入国家。越来越多的临床病例表明清除Tp感染需要加强公共卫生筛查和治疗,而接种疫苗是预防Tp感染极有价值和首选的方法。本文概述了研制Tp疫苗的必要性,总结疫苗研究过程中候选抗原的相关信息及递送系统,分析Tp疫苗发展策略。
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| 关 键 词： | 梅毒螺旋体苍白亚种 疫苗 候选抗原 递送系统 发展策略 |
Vaccine development for syphilis |
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| ZHENG Kang,LIU Anyuan,WU Yimou. Vaccine development for syphilis[J]. Journal of Microbes and Infection, 2019, 14(3): 180-184. DOI: 10.3969/j.issn.1673-6184.2019.03.007 |
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| Authors: | ZHENG Kang LIU Anyuan WU Yimou |
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| Affiliation: | 1. Institution of Pathogenic Biology, Medical College, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China; 2. The Second Affiliated Hospital of University of South China, Hengyang 421001, China |
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| Abstract: | Syphilis is a sexually transmitted infection caused by Treponema pallidum subsp. Pallidum (T. pallidum), Over 90% of syphilis cases occur in low- and middle-income countries. Studies indicated that elimination of T. pallidum requires enhanced public health screening, treatment and vaccination. This article provides an overview of the need for development of a syphilis vaccine, summarizes the information and delivery system and candidate antigens in development, and analyzes the development strategies for T. pallidum vaccine. |
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| Keywords: | Treponema pallidum subsp. pallidum Vccine Candidate antigens Delivery system Development strategy |
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