Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs |
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| Authors: | Rasimas Joseph J Kar Sambit R Pegg Anthony E Fried Michael G |
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| Institution: | Department of Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA. |
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| Abstract: | The O6-alkylguanine-DNA alkyltransferase (AGT) repairs O6-alkylguanine and O4-alkylthymine adducts in single-stranded and duplex DNAs. Here we characterize the binding of AGT to single-stranded DNAs ranging in length from 5 to 78 nucleotides (nt). Binding is moderately cooperative (37.9 +/- 3.0
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