Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells |
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Authors: | Nicole M Chapman Mahmood Y Bilal Noemi Cruz-Orcutt Cory Knudson Sofia Madinaveitia Jonathan Light Jon CD Houtman |
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Institution: | 1. Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, United States;2. College of Dentistry, University of Iowa, Iowa City, IA 52242, United States;3. Department of Microbiology Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States |
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Abstract: | Toll-like receptor 2 (TLR2) serves as a co-stimulatory receptor for human T cells by enhancing T cell receptor (TCR)-induced cytokine production and proliferation. However, it is unknown where signals from the TCR and TLR2 converge to enhance T cell activation. To address this gap, we examined changes in TCR-induced signaling following concurrent TLR2 activation in human T cells. Both proximal TCR-mediated signaling and early NFκB activation were not enhanced by TCR andTLR2 co-activation, potentially due to the association of TLR2 with TLR10. Instead, TLR2 co-induction did augment Akt and Erk1/Erk2 activation in human T cells. These findings demonstrate that TLR2 activates distinct signaling pathways in human T cells and suggest that alterations in expression of TLR2 co-receptors may contribute to aberrant T cell responses. |
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