High parental age is associated with sporadic hereditary retinoblastoma: the Dutch retinoblastoma register 1862–1994 |
| |
Authors: | A C Moll Saskia M Imhof D Joop Kuik L M Bouter W Den Otter P Dick Bezemer J W Koten Karel E W P Tan |
| |
Institution: | (1) Department of Ophthalmology, Free University Hospital, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands, NL;(2) Tel.: +31-20-4444795; Fax: +31-20-4444745,;(3) Department of Epidemiology and Biostatistics, Free University, Amsterdam, The Netherlands, NL;(4) Department of Functional Morphology, Utrecht University, Utrecht, The Netherlands, NL |
| |
Abstract: | We wished to determine the influence of parental age at the birth of a retinoblastoma patient on the risk of sporadic hereditary
retinoblastoma. The parental age at birth of 941 patients of the Dutch retinoblastoma register (1862–1994) was identified
and compared between sporadic hereditary and nonhereditary patients. In a subcohort (1936–1994), a comparison was made with
parental age at birth in the general population, as obtained from the Central Bureau of Statistics. Missing birth dates of
the parents of retinoblastoma patients were traced with the help of the municipal registries and the Central Bureau of Genealogy.
The mean paternal age was 10.7 months higher and the mean maternal age was 11.0 months higher in the sporadic hereditary retinoblastoma
patients than in parents of nonhereditary patients. In the subcohort, the mean paternal and maternal ages of sporadic hereditary
patients were also higher (12.4 and 11.5 months, respectively) than those of the general population. All differences were
statistically significant. This study shows that a high parental age is associated with an enhanced risk of sporadic hereditary
retinoblastoma.
Received: 10 November 1995 / Revised: 11 January 1996 |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|