Synthesis and antiproliferative activity in vitro of novel (2-butynyl)thioquinolines |
| |
Authors: | Mól W Matyja M Filip B Wietrzyk J Boryczka S |
| |
Institution: | Department of Organic Chemistry, The Medical University of Silesia, 41-200 Sosnowiec, PL, Poland. |
| |
Abstract: | The series of new acetylenic thioquinolines containing propargyl, 2-butynyl, 4-bromo-2-butynyl, and 4-hydroxy-2-butynyl groups has been prepared and tested for antiproliferative activity in vitro against human SW707 (colorectal adenocarcinoma), CCRF/CEM (leukemia)] and murine P388 (leukemia), B16 (melanoma)] cancer lines. All the compounds obtained exhibited antiproliferative activity. The most active compounds 7, 16, 17, and 19 have the ID(50) values ranging from 0.2 to 4.6 microg/ml comparable to that of cisplatin used as reference compounds. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|