Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment |
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Authors: | Kim Dong-Hwan Hong Bin Na Le Hoa Thi Hong Ha Na Lim Choon Woo Park Keun Ha Kim Tae Woo Kang Tong Ho |
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Affiliation: | Graduate School of East-West Medical Science, Kyung Hee University, Gyeonggi-do 449-701, Republic of Korea. |
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Abstract: | Diosgenin was modified to control its in vivo bioavailability by conjugating a hydrophilic unit, tetraethylene glycol. The diosgenin-tetraethylene glycol conjugate (TE) was orally administered in streptozotocin induced diabetic mice for this auditory protection study. The bioactivity improvement of TE for in vivo diabetic auditory impairment treatment was clearly observed in three different auditory tests and compared with that of diosgenin. The improvement in in vivo efficacy suggests that the small molecular weight PEGylation of diosgenin is a synthetically robust and systematically applicable strategy to reform the poor pharmacokinetics of a hydrophobic aglycone. |
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