<Emphasis Type="Italic">In vivo</Emphasis> Role of the UV-Endonuclease from <Emphasis Type="Italic">Micrococcus luteus</Emphasis> in the Repair of DNA |
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| Authors: | INGA MAHLER SIDNEY R KUSHNER LAWRENCE GROSSMAN |
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| Institution: | 1.Graduate Department of Biochemistry,Brandeis University,Waltham;2.Department of Molecular Biology,University of California,Berkeley |
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| Abstract: | THE UV-endonuclease enzyme of Micrococcus luteus causes single strand breaks in vitro adjacent to or one nucleotide removed from pyrimidine dimers produced in DNA by ultraviolet irradiation1–4. Excision of the dimers is catalysed by a second enzyme, the UV-exonuclease1,5. We now report the isolation of strains of M. luteus which possess altered levels of UV-endonuclease. Mutants lacking this enzyme are incapable of excising thymine-containing dimers while strains with decreased UV-endonuclease activity repair more slowly than wild type cells. |
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