Phospholipase A2 inhibitors from marine algae |
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| Authors: | Mayer Alejandro M. S. Paul Valerie J. Fenical William Norris James N. de Carvalho M. S. Jacobs Robert S. |
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| Affiliation: | (1) Louisiana State University Medical Center, Department of Physiology, 1901 Perdido Street, 70112-1393 New Orleans, LA, USA;(2) University of Guam - Marine Laboratory, UOG Station, 96923 Mangilao, Guam, USA;(3) Scripps Institution of Oceanography, University of California - San Diego, 92093-0236 La Jolla, CA, USA;(4) Department of Botany, NH B166, National Museum of Natural History, Smithsonian Institution, 20560 Washington, D. C., USA;(5) Department of Biological Sciences, University of California-Santa Barbara, 93106 Santa Barbara, CA, USA |
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| Abstract: | Twelve out of twenty-nine compounds isolated from benthic marine algae from the phyla Chlorophyta, Phaeophyta and Rhodophyta have been found to be potent inhibitors of bee venom derived phospholipase A2 (PLA2) (> 50%) in the  M range. The compounds investigated were from: Bryopsis pennata, Rhipocephalus phoenix, Caulerpa prolifera, C. racemosa, C. bikinensis, Cymopolia barbata, Laurencia cf. palisada, Laurencia sp., Ochtodes crockeri, Liagora farinosa, Sphaerococcus coronipifolius, Phacelocarpus labillardieri, Dictyota sp., B furcaria galapagensis, Stypopodium zonale, Dictyopteris undulata, Stoechospermum marginatum, Dictyopteris divaricata, Dilophus fasciola and Dilophus sp. This is the first report of bee venom PLA2 inhibition in vitro by pure compounds isolated from marine algae. |
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| Keywords: | phospholipase A2 inhibitors marine algae marine secondary metabolites Rhodophyta Phaeophyta Chlorophyta marine natural products |
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