Cholesterol content and metabolism in normal and polyoma virus-transformed hamster embryo fibroblasts |
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| Authors: | D. Mark-Malchoff G. V. Marinetti J. D. Hare A. Meisler |
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| Affiliation: | University of Rochester School of Medicine and Dentistry, Departments of Biochemistry, Microbiology and Medicine, Rochester, NY 14642, USA |
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| Abstract: | The total cholesterol content of normal hamster embryo fibroblasts and polyoma virus-transformed hamster embryo fibroblasts were found to be similar. However, the free cholesterol: cholesterol ester ratio was 41.5 in normal cells as contrasted to 1.8 in their transformed counterparts. This difference is due in part to an increase in cholesterol esterification and a decrease in the hydrolysis of cholesterol esters in the transformed cell. |
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