Inhibition by Retinoic Acid of Albumin and DNA Synthesis in Adult Rat Hepatocytes

RA down-regulated albumin and DNA synthesis of adult rat hepatocytes in a dose-dependent manner at dose ranges of 10^?9–10^?5 m. 10^?5 m of RA decreased albumin synthesis as well as growth factors EGF, aFGF, bFGF, and HGF-induced DNA synthesis to half of the control. These inhibitory effects of RA were not a consequence of the toxicity of RA to hepatocytes.