A Marine Carotenoid,Fucoxanthin, Induces Regulatory T Cells and Inhibits Th17 Cell Differentiation in Vitro |
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Abstract: | Fucoxanthin is a non-provitamin A carotenoid contained in brown seaweeds. We found that it suppressed interleukin-17 secretion from CD4+ T cells under IL-17-producing T (Th17) cell development conditions. By evaluating T cell differentiation in vitro, fucoxanthin and its metabolite fucoxanthinol inhibited T cell differentiation into Th17 cells. This suggests that fucoxanthin can improve inflammatory diseases due to Th17 cells. |
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Keywords: | fucoxanthin interleukin-17 interleukin-17-producing T (Th17) cell regulatory T cell |
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