A Role of a Lymphocyte Tryptase,Granzyme A,in Experimental Ulcerative Colitis |
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| Abstract: | In the large-intestinal mucosae of rats orally administered dextran sulfate sodium, which induces an enteritis resembling ulcerative colitis (UC), the activity for granzyme A, a lymphocyte tryptase, increased at an earlier stage than that at which UC markers (growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 and caspase-3) increased. This suggests involvement of the enzyme in the exacerbation and perpetuation of enteritis. |
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| Keywords: | granzyme A cytotoxic T-lymphocytes ulcerative colitis dextran sulfate sodium pancreatic secretory trypsin inhibitor |
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