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Synthesis of (2RS,8R,10R)-YM-193221 and an Improved Approach to Tyroscherin,Bioactive Natural Compounds from Pseudallescheria sp. |
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| Abstract: | Short-step syntheses of (2RS,8R,10R)-YM-193221 (1) and tyroscherin (2), which are biologically active compounds isolated from Pseudallescheria sp., were accomplished in six and eight steps from L-tyrosine. The relative stereochemistry of natural YM-193221 was determined to be 8R *,10R *. |
| Keywords: | YM-193221 tyroscherin total synthesis |