A Simple and Improved Synthesis of p-Boronophenylalanine,a Boron Carrier for the Boron-Neutron Capture Therapy

An improved synthesis of BPA was achieved by a four-step sequence starting from p-formylbenzenebroronic acid (1) and ethyl isocyanoacetate via an ethyl α-formylaminocinnamate derivative (3) in a good overall yield.