Hydrolysis of Glycerophosphocholine Hydroperoxide by Phospholipase A2

In a sodium deoxycholate micellar solution with calcium chloride, a synthetic phospholipid hydroperoxide was hydrolyzed by porcine pancreatic phospholipase A₂ (PLA₂) and the reactivity observed for the hydroperoxide was demonstrated to be higher than the case with the unoxidized form. In these systems, it was found that the hydroperoxy group did not directly activate the PLA₂.