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Antibacterial Agents that Inhibit Histidine Protein Kinase YycG of Bacillus subtilis |
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| Abstract: | We demonstrated in vitro that YycG-YycF of Bacillus subtillis constitutes a two-component system and shows a specificity of the sensor protein for the cognate phosphorylation partner. Based on inhibition of such an autophosphorylation of YycG, we searched imidazole and zerumbone derivatives to identify the antibacterial agents such as NH125, NH126, NH127, and NH0891. |
| Keywords: | two-component system signal transduction histidine kinase inhibitors antimicrobial agents |