Nicotine and hippocampus-dependent learning |
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Authors: | Thomas J Gould |
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Institution: | (1) Department of Psychology, Temple University, Philadelphia, PA |
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Abstract: | Addiction is a complex disorder because many factors contribute to the development and maintenance of addiction. One factor
is learning. For example, drug-context associations that develop during drug use could facilitate drug craving upon re-exposure
to contexts previously associated with drugs. Additionally, deficits in cognitive processes associated with withdrawal could
precipitate relapse in attempts to ameliorate those deficits. Because addiction and learning involve common neural areas and
cell signaling cascades, addiction-related changes in processes underlying plasticity may contribute to addiction. This article
examines similarities between addiction and learning at the behavioral, neural, and cellular levels, with emphasis on the
neural substrates underlying the effects of acute nicotine, chronic nicotine, and withdrawal from chronic nicotine on hippocampus-dependent
contextual, learning. |
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Keywords: | Learing addiction acetylcholine nicotine hippocampus contextual fear conditioning CREB MAPK withdrawal plasticity |
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