Sequence of a sea urchin hsp70 gene and its 5' flanking region |
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Authors: | M La Rosa G Sconzo G Giudice M C Roccheri M Di Carlo |
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Institution: | Dipartimento di Biologia Cellulare e dello Sviluppo, Università di Palermo, Italy. |
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Abstract: | We report the nucleotide sequence of a 4470-bp fragment derived from a sea urchin genomic clone containing part of a heat-shock protein 70 (Hsp70)-encoding gene. This fragment, named hsp70 gene II, contains 1271 bp of the flanking region and 3299 bp of structural gene sequence interrupted by five introns and encoding the N-terminal 371 amino acids (aa) of the protein. The 5' flanking region contains a putative TATA element, two CCAAT boxes, four heat-shock consensus sequence elements (hse) and one consensus sequence for binding of Sp1. Remarkable homologies were observed for deduced aa sequence and intron-exon organization between hsp70 gene II and rat hsc73 gene. |
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