Novel polyhydroxysterols from the Red Sea marine sponge Lamellodysidea herbacea |
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Authors: | Sauleau Pierre Bourguet-Kondracki Marie-Lise |
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Institution: | Laboratoire de Chimie, UMR 5154 CNRS, Muséum National d' Histoire Naturelle, 63 rue Buffon, 75231 Paris Cedex 05, France. |
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Abstract: | Chemical investigation of the dichloromethane extract of the Red Sea marine sponge Lamellodysidea herbacea led to the isolation of four novel polyhydroxysteroids: cholesta-8-en-3beta,5alpha,6alpha,25-tetrol (1), cholesta-8(14)-en-3beta,5alpha,6alpha,25-tetrol (2), cholesta-8,24-dien-3beta,5alpha,6alpha-triol (3), and cholesta-8(14),24-dien-3beta,5alpha,6alpha-triol (4). Their structures were identified through 1D and 2D NMR studies. Relative stereochemistries were established by analysis of chemical shifts, coupling constants, and NOESY correlations. Compounds 3-4 showed antifungal activity against Candida tropicalis, with an inhibition diameter of 13 and 11 mm at 10 microg/disc, respectively. |
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Keywords: | Sponge Lamellodysidea herbacea Polyhydroxysterol Antifungal activity |
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