Effect of peripherally-injected glucagon-like peptide-1 on gastric mucosal blood flow |
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Authors: | Naciye Isbil-Buyukcoskun Betul Cam-Etoz Guldal Gulec Kasim Ozluk |
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Affiliation: | aUludag University Medical Faculty, Department of Physiology, 16059, Gorukle, Bursa, Turkey |
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Abstract: | The aim of this study was to investigate the mechanisms involved in the effect of glucagon-like peptide-1 (GLP-1) on the decrease in gastric mucosal blood flow (GMBF) induced by intragastric ethanol.After preparation of the stomach for GMBF recording, a probe was placed to the gastric mucosa and basal GMBF recordings were obtained by a laser Doppler flowmeter after a 30-minute stabilization period. Following GLP-1 (1000 ng/kg; i.p.) injection, 1 ml of absolute ethanol was applied to the gastric chamber and GMBF was recorded continuously during a 30-minute period. GLP-1 (1000 ng/kg; i.p.) prevented the decrease in GMBF induced by ethanol. Nitric oxide (NO) synthase inhibitor L-NAME, (30 mg/kg; s.c.), calcitonine gene-related peptide (CGRP) receptor antagonist CGRP-(8–37) (10μg/kg; i.p.), and cyclooxygenase inhibitor indomethacin (5 mg/kg; i.p.) all inhibited the GMBF-improving effect of GLP-1.We concluded that, NO, CGRP and prostaglandins may be involved in the effect of peripherally-injected GLP-1 on GMBF reduction induced by intraluminal ethanol. |
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Keywords: | GLP-1 Ethanol Gastric mucosal blood flow L-NAME CGRP-(8– 37) Indomethacin |
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