Aeromonas sobria hemolysin causes diarrhea by increasing secretion of HCO3- |
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| Authors: | Takahashi Akira Nakano Masayuki Okamoto Keinosuke Fujii Yoshio Mawatari Kazuaki Harada Nagakatsu Nakaya Yutaka |
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| Institution: | Department of Nutrition and Metabolism, The University of Tokushima Graduate School, Institute of Health Biosciences, Tokushima City, Tokushima, Japan. akiratak@nutr.med.tokushima-u.ac.jp |
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| Abstract: | Aeromonas sobria hemolysin (ASH) is one of the major virulence factors produced by A. sobria, a causative agent of diarrhea in humans. We investigated the effects of ASH on anion transport in human colonic epithelial cells. ASH increased short circuit currents across the intestinal epithelia, which were suppressed by anion channel antagonists, such as carbonic anhydrase inhibitors, and by the removal of external HCO3-. Iliac fluid accumulation was also inhibited by carbonic anhydrase inhibitors. The results suggest that ASH activates HCO3- secretion, whose level correlates with the severity of diarrhea. |
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| Keywords: | Aeromonas sobria hemolysin (ASH) short circuit currents (Isc) cystic fibrosis transmembrane conductance regulator (CFTR) HCO3? secretion |
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