| Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma? |
| |
| 作者姓名： | Weiner OD |
| |
| 摘 要： |
|
Rac Activation: P-Rex1 — A Convergence Point for PIP3 and Gβγ? |
| |
| Weiner OD.Rac Activation: P-Rex1 — A Convergence Point for PIP3 and Gβγ?[J].Current Biology,2002,12(12):R429-R431. |
| |
| Authors: | Weiner Orion D |
| |
| Institution: | Department of Cell Biology, Harvard Medical School, 240 Longwood Ave/ C-1, 502, Boston, Massachusetts 02115, USA. orion_weiner@hms.harvard.edu |
| |
| Abstract: | P-Rex1, a novel Rac activator, has been identified in the first biochemical purification of a guanine nucleotide exchange factor for GTPases of the Rho family. P-Rex1 is synergistically activated by PIP(3) and Gbetagamma and may act as a coincidence detector for these signaling molecules. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
