Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[a,g]fluorenylium derivative |
| |
| Authors: | Juskowiak Bernard Galezowska Elzbieta Koczorowska Natalia Hermann Tadeusz W |
| |
| Institution: | Faculty of Chemistry, A. Mickiewicz University, 60-780 Poznan, Poland. juskowia@amu.edu.pl |
| |
| Abstract: | The aggregation and DNA binding behavior of a new G-quadruplex selective ligand, 6a,12a-diazadibenzo-a,g]fluorenylium derivative, was studied by UV-vis absorption and fluorescence spectroscopy. The formation of ligand aggregates with different spectral characteristics was observed at low and high concentration of NaCl, respectively. The ligand binds to G-quadruplex with much higher affinity than to single- and double-stranded DNA. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
