Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer |
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| Authors: | Zheng Gang Li Hui Zhang Min Lund-Katz Sissel Chance Britton Glickson Jerry D |
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| Affiliation: | Department of Radiology, University of Pennsylvania Medical School, Philadelphia 19104, USA. zheng@rad.upenn.edu |
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| Abstract: | To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that this photosensitizer-reconstituted LDL can be internalized via LDLr by human hepatoblastoma G(2) (HepG(2)) tumor cells. |
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