Detection of the deletion of interferon-alpha and beta genes in lymphoblastoid cells by PCR] |
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| Authors: | M Kita L J Tong E Nakajima A Yamada O Sasaki N Yamaguchi T Kishida J Imanishi |
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| Institution: | Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japan. |
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| Abstract: | The HuIFN-alpha and beta genes were examined by the PCR method in the 11 human lymphoblastoid cell lines. The results showed that the homozygous deletion of HuIFN-alpha and beta genes was detected in 5 of 11 cell lines and in 5 of 11 cell lines, respectively. The deletions of both the HuIFN-alpha and beta genes were observed in 4 of 11 cell lines. One T cell leukemia cell line deleted only HuIFN-alpha gene, while the other T cell leukemia line deleted only HuIFN-beta gene. This suggests that the deletions of HuIFN-alpha and beta genes may be related the development of leukemia or lymphoma. |
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