Synthesis of cyclic ADP-carbocylcic-xylose and its 3"-O-methyl analogue as stable and potent Ca2+ -mobilizing agents |
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| Authors: | Kudoh Takashi Matsuda Akira Shuto Satoshi Murayama Takashi Ogawa Yasuo |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan. |
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| Abstract: | We previously showed that 3"-deoxy-cyclic ADP-carbocyclic-ribose (3"-deoxy-cADPcR, 3) is a stable and highly potent analogue of cyclic ADP-ribose (cADPR, 1), a Ca2+ -mobilizing second messenger. From these results, we newly designed another 3"-modified analogues of cADPcR and identified the N1-"xylo"-type carbocyclic analogue, i.e., cADPcX (4), as one of the most potent cADPR-related compounds reported so far. |
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