| 消炎痛致胃粘膜损伤时胃组织胺含量变化及甲氰咪胍的影响 |
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| 引用本文： | 梁心平,杨素娟.消炎痛致胃粘膜损伤时胃组织胺含量变化及甲氰咪胍的影响[J].中国应用生理学杂志,1990,6(1):55-58. |
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| 作者姓名： | 梁心平 杨素娟 |
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| 作者单位： | 总后医学专科学校生理学教研室，军事医学科学院放射医学研究所 北京 |
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| 摘 要： | 消炎痛可引起小鼠胃粘膜损伤,在一定剂量范围内,其剂量和胃粘膜损伤程度之间有明显的量效关系。在引起胃粘膜损伤时,胃组织胺含量相应增加,大剂量重度损伤时尤为明显。预先用甲氰咪胍灌胃,可明显减轻损伤并降低组织胺含量。提示组织胺参与消炎痛致胃粘膜损伤过程并对损伤产生一定影响。
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| 关 键 词： | 消炎痛 胃粘膜损伤 组织胺 甲氰咪胍 |
THE CHANGE OF GASTRIC HISTAMINE CONTENT IN INDOCIN-INDUCED GASTRIC MUCOSAL INJURY AND THE EFFECT OF CIMETIDINE |
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| Liang Xinping,Yang Sujuan.THE CHANGE OF GASTRIC HISTAMINE CONTENT IN INDOCIN-INDUCED GASTRIC MUCOSAL INJURY AND THE EFFECT OF CIMETIDINE[J].Chinese Journal of Applied Physiology,1990,6(1):55-58. |
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| Authors: | Liang Xinping Yang Sujuan |
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| Abstract: | In the present study, it was indicated that indocin could induce gastric injury rapidly. In certain range of doses the degree of mucosal injury was correlated with the dose of the drug. The gastric histamine content increased during injury, especially in large doses. Pre-administration of cimetidine could reduce significantly the injury and the histamine content of gastric mucosa. It is considered that histamine may play a certain role in the mechanism of indocin-induced gastric mucosal injury. |
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| Keywords: | indocin gastric mucosal injury histamine cimetidinu |
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