| 吸烟对大鼠肺循环血流动力学及肺血管反应性的影响 |
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| 引用本文： | 胡清华 赵海波. 吸烟对大鼠肺循环血流动力学及肺血管反应性的影响[J]. 中国应用生理学杂志, 1990, 6(1): 62-65 |
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| 作者姓名： | 胡清华 赵海波 |
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| 作者单位： | 同济医科大学病理生理学教研室 武汉(胡清华，赵海波，张然，何丽萍，冯长建)，同济医科大学病理生理学教研室 武汉(王迪浔) |
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| 摘 要： | 本实验用大鼠29只,进行人工通气吸入烟气,初步探讨了吸烟对肺循环的影响。其中7只观察了吸烟对肺循环血流动力学的直接影响,结果表明,吸烟可致右心室收缩压、心输出量下降及心率减慢,肺循环阻力无明显改变。观察22只大鼠吸烟后缺氧所致肺循环血流动力学变化,结果表明,吸烟可使缺氧性肺血管反应降低,而且发生在肺循环血流动力学变化之前。
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| 关 键 词： | 吸烟 肺循环血流动力学 肺血管反应性 |
EFFECTS OF CIGARETTE SMOKING ON PULMONARY HEMODYNAMICS AND PULMONARY VASOREACTIVITY TO ACUTE HYPOXIA IN RATS |
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| Hu Qinghua,Zhao Haibo,Zhang Ran,He Liping,Feng Changjian,Wang Dixun. EFFECTS OF CIGARETTE SMOKING ON PULMONARY HEMODYNAMICS AND PULMONARY VASOREACTIVITY TO ACUTE HYPOXIA IN RATS[J]. Chinese journal of applied physiology, 1990, 6(1): 62-65 |
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| Authors: | Hu Qinghua Zhao Haibo Zhang Ran He Liping Feng Changjian Wang Dixun |
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| Abstract: | Effects of cigarette smoking for 30 min on pulmonary hemodynamics were studied in 7anesthetized Sprague-Dawley rats. Right ventricular systolic pressure (RVSP), cardiac output (CO), stroke volume (SV), and heart rate (HR) decreased significantly during smoking for 10-15 min, while pulmonary, vascular resistance (PVR) remained unchanged during cigarette smoking. The effect of smoking on pulmonary vasoreactivity to hypoxia was studied in 22 anesthetized Sprague-Dawley rats. The result showed that cigarette smoking for 5 min caused a significant depression of pulmonary vasoreactivity to hypoxia. |
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| Keywords: | cigarette smoking pulmonary hemodynamics pulmonary vasoreactivity |
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