Chronic effects of acetylmethadol and methadone in rhesus monkeys. |
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| Authors: | D A Downs D J Thomas M C Braude |
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| Affiliation: | 1. Warner-Lambert/Parke-Davis Pharmaceutical Research Division Department of Pharmacology 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA;1. National Institute on Drug Abuse Biomedical Branch 11400 Rockville Pike, Rockville, Maryland, USA |
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| Abstract: | Chronic treatment for 12 weeks in rhesus monkeys with α-?-acetylmethadol (LAAM) or methadone failed to cause clinically significant changes in various parameters of blood biochemistry, hemotology, or liver function. However, one of four monkeys showed recurrent episodes of LAAM-induced depression during the 12-week period of chronic treatment. |
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